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Anti-Smoking Drugs Have 'Relatively Small' Health Benefit: Report
Premier Clark's promise to pay for them may waste, not save, B.C. health care dollars.
The B.C. government's plan to crush smoking habits might not be as cost-effective as it claims.
When Premier Christy Clark announced the British Columbian government will be paying for products to help people quit smoking, she suggested it will save taxpayers money.
But that position contradicts the conclusion of a government-funded agency whose job it is to help officials "make informed decisions in health care" based on evidence.
When people smoke, there are impacts not just on them and the people around them, but "there are the impacts on all of us who pay taxes and depend on a health care system to be there when we need it," said Clark in a video announcing the new policy on the government's website.
"By reducing the number of people who smoke, not only will we prevent or delay the onset of diseases like heart attacks and cancer, but also avoid the millions of dollars cost on our health care system," said Health Minister Mike de Jong in the accompanying press release.
And the B.C. Medical Association's president-elect, pediatrician Nasir Jetha, was quoted calling stop-smoking medications "one of health care's most cost-effective measures in reducing death, disease and medical costs."
If they are correct, it would be an easy decision for public health systems to pay for the medicines, but few do. In Canada, provincial governments in just Saskatchewan and Quebec fund the prescription drugs Clark announced B.C.'s PharmaCare system will pay for starting at the end of September.
And France, the Tyee reported this week, decided that due to concerns about adverse reactions, it would stop paying for one of the two drugs that B.C. plans to fund.
Seeking the evidence
In a 548-page report dated September 2010, the Canadian Agency for Drugs and Technology and Health (CADTH) took a close look at the drugs and treatments used to help people quit smoking.
The CADTH is a non-profit agency that the federal, provincial and territorial governments fund to provide decision-makers with "the evidence, analysis, advice, and recommendations they require to make informed decisions in health care."
In the report Pharmacologic-based Strategies for Smoking Cessation, it looked at nicotine replacement therapies (gum and patches), and the antidepressants varenicline (sold as Champix in North America and Chantix in Europe) and buproprion (sold as Zyban and as a generic). These are the same therapies the B.C. government has said it will provide.
The report considered both whether the different products worked and whether it was cost effective for health care systems to provide them.
The report did find that all the treatments worked better than doing nothing. "Varenicline, bupropion, and NRT are all effective in helping the general population quit smoking and remain smoke-free one year later," it found. They doubled, and in the case of varenicline possibly tripled (though they cautioned most of the studies were funded by varenicline maker Pfizer), the odds of a person quitting when compared with not using a drug therapy.
'Relatively small' benefits
But the authors also found that providing them does not save health care providers money.
"The cost of providing smoking cessation pharmacotherapy is greater than the future costs of treating smoking-related illness," they found, according to a summary for decision-makers, though it noted governments might prefer to fund prevention rather than treating disease later.
As for the health benefits, they said, they are "relatively small" at an "average of four to 18 days of perfect health for all smokers who attempt to quit."
In other words, for the few who succeed at quitting, the drugs can make a large difference, but many smokers will not succeed even with the drugs' help. In the summary's words, "When the health benefit gained by the smokers who succeed in quitting is equally divided among all those who attempt it, the average health gain is small."
From a health care provider's point of view, needing to make good use of public money, every "quality-adjusted life-year" gained by providing the treatments costs in the range of between $4,000 and $10,000, it said.
B.C. is planning to spend as much as $25 million a year providing smoking cessation products, depending how many people take advantage of the program.
The Tyee sought explanations from Premier Clark's office, the Health ministry and the B.C. Medical Association on their statements' contradiction with the CADTH findings and why they believed providing the products would save taxpayer dollars.
Cost just one factor: ministry
"The cost to the health care system is only one of the components we're looking at with our decision to cover the medications and other nicotine replacement therapies," said Health ministry spokesperson Ryan Jabs in an email. "There's also a large cost to the B.C. economy (estimated at $2.3 billion annually) as well as -- and more importantly -- a significant emotional and psychological cost experienced by families, friends and people who have to go through treatment for cancer or other diseases related to tobacco use."
Health ministry officials couldn't find the basis for the CADTH conclusion in the report, but have contacted the authors, he said.
The CADTH report also said there is "a need to consider smoking cessation strategies" given "the number of preventable deaths and evidence indicating that more than 30 per cent of Canadian hospital beds are occupied by adults who are there as a consequence of their smoking habits," he pointed out.
BCMA spokesperson Sharon Shore provided a link to a Canadian Medical Association Journal article encouraging governments to pay for smoking cessation therapies. The article argues that "smoking cessation medications appear more cost-effective than many other primary preventive interventions, such as those for hypertension or hypercholesterolemia."
A spokesperson in Clark's office did not respond by posting time.
Clark had promised during her campaign to lead the BC Liberal Party to use public money to pay for "nicotine replacement therapies and cessation products," saying it would lead to a healthier population, lower cancer rates and reduced impact on the health care system.
"Who do you trust, the people who just look at the science, or the people concerned about the politics of it?" asked health researcher and author Alan Cassels.
Decision-makers should be comparing the drugs not against smoking, but against other techniques for quitting, he said. It's not clear that any additional benefit from using Champix compared to nicotine replacement patches or gum outweighs the added risk of adverse reactions associated with the drug, he said.
Without funding the treatments, B.C. has achieved a relatively low smoking rate already, he said. "We're doing something right," he said, suggesting the success has been largely thanks to social regulations that have put an end to smoking in bars, restaurants, offices and public places. ![]()



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Van Isle
50 weeks ago
How many people who have
How many people who have read this article, use to be smokers? I was and quit 26 years ago.
Loretta
50 weeks ago
supportive stance
I am someone who quit over 9 months ago using a combination of therapies. I wasn't even that convinced it would work but, because I have extended health benefits that do pay for these drugs, I gave it a try. Now I am several months smoke-free with very little difficulty.
I think the fact that the programs do help in overall to the general population is a bit of a red herring. So far, the attempt to shift public opinion has resulted in shame, blame, the ostrasization and heaps of moral judgment upon smokers. By covering the cost of these programs, the province is saying that they are taking a positive and supportive stance in helping people break the habit and become healthier.
Also, the studies of quitting smoking indicate that, on average, it takes 7 attempts to quit before someone quits for the one-year period that's considered to be success. Knowing this, if we say we stand behind people trying to break the addiction, I say that it's great we're talking about moving away from shame and blame into adopting some of the tools (and yes, there are others) that help.
Ms. Clark very seldom receives my support but on this position, she's got it.
snert
50 weeks ago
Numbers are fun
Number of smokers in BC - 524,592
http://www.cadth.ca/media/pdf/CADTH_Smoking_Cessation_Summary_for_Decision-makers_e.pdf
Tobacco Tax 18.5 cents a cigarette or $3.70/pack.
http://www.sbr.gov.bc.ca/documents_library/bulletins/tta_005.pdf
Assuming each one of the smokers has a pack a day habit.
524,592 x 3.70 x365 = $708,461,496
Now I haven't factored in the HST or any federal taxes but $708,461,496 per year is a pretty big revenue hit for the province if everybody quit.
It seems that cost of the program could be more than meets the eye.
Booker
50 weeks ago
quit
I quit after about 15,000 attempts. Nicotine gum helped. I think that this is one area that our health care system should not cover. I'd rather see the funds spend on areas where there are clearer benefits and better rates of success. The cost to individuals of these products is not onerous, especially when compared to cost of smoking itself.
JohnRPolito
50 weeks ago
Clark and CADTH ignore quit meds real-world ineffectiveness
B.C. is about to spend $25 million for quitting products which consistently clobber placebo inside randomized clinical trials, yet cannot defeat real-world cold turkey quitters. But how, why?
Think about it. Placebo isn't a real quitting method. Unlike the cold turkey quitter who expects to encounter and navigate full-blown withdrawal, the placebo group joined the trial hoping for medication that would diminish their withdrawal syndrome. In reality, none of the placebo-controlled trials cited in the CADTH report were blind, as you cannot hide the onset of full-blown withdrawal from experienced quitters who have become experts at knowing exactly how it feels. It's why 2 to 4 times as many within the placebo group are able to correcting guess their randomized assignment as guess wrong. Placebo-controlled cessation trial findings reflect frustrations not efficacy.
Annual UK NHS Stop Smoking Services data consistently shows non-medication quitters doing as well as or better than NRT at 4 weeks, when medication quitters still have another 4 to 8 weeks of treatment prior to attempting physical withdrawal and adjustment to natural dopamine pathway stimulation.
If I were a Canadian/B.C. health official I'd demand an immediate yet inexpensive real-world quitting method survey to determine whether or not these products where doing more good than harm. And I would not allow any financially conflicted researcher to have any survey role whatsoever. I submit that all real-world evidence to date suggests that long-term results (6 months/1 year) would show that Canadian quitting med use is actually undercutting successful cessation. Sadly, the medicinization of smoking cessation has brought decline in adult smoking to near standstill.
Regards,
John R. Polito
Nicotine Cessation Educator
Loretta
50 weeks ago
financially conflicted
I recognize that there are huge conflict of interest issues here and that was, in part, what made me doubt the effectiveness of the therapies I chose.
However, it worked for me. That's anecdotal evidence and not worth anything, really.
The moral tone that pervades discussions about quitting is quite disturbing and not helpful.
I would agree that NRT is likely not very helpful in terms of six month/one year quit rates. However, I would suggest that the rates of smokers is at the point where one is no longer able to pick off the low-hanging fruit, as it were.
john corsiglia
50 weeks ago
Quit Smoking!
I quit a heavy tobacco habit of many years by taking a shower every time I craved a smoke. After two days and a lot of showers the cravings ended permanently.
Oldcougar
50 weeks ago
Nicotine Health Benefits???
Just wanted to mention that nicotine has been found to be beneficial in preventing Parkinson's Disease & in treatment for Colitis, Crohn's & other diseases. My son's Colitis specialist recommended he chew tobacco.
Having read a few study results on both smoking cessation drugs on the adverse complications (sometimes resulting in death) I wouldn't want any member of my family taking them. Cold turkey with counselling seems a better option.
I'm wondering why nobody studies alcohol use & abuse, as smokers are often heavy drinkers. According to studies I've read, alcohol abuse is a major cause of death from heart attacks, strokes & other diseases, far outnumbering the deaths due to smoking. Alcohol is also beneficial to health if you keep it to 1 or 2 drinks per day.
It appears that moderation is the key.
Oldcougar
50 weeks ago
I'm also wondering???
I'm also wondering if some of the diseases & deaths attributed to smoking aren't related to pollution, either in the work place or on the street. Has it been far easier for the political establishment backed by employers to go after the sins of the smokers than to clean up exhaust fumes? If everyone quit smoking today would the rate of diseases like asthma, emphysema, allergies & others drop significantly? Or would they still be writing tobacco use as cause of death because someone of 75 died & they smoked in their 20's?
A Voice
50 weeks ago
As a ex smoker, I can attest
As a ex smoker, I can attest to the effectivety of Champix. What I'd really like to see is what wold happen to your taxes if avery one who smokes in Canada actually quit...and you thought the HST was bad. We should thank the smokers in our population for keeping our taxes down. Most smokers die early, saving you extended pension costs, healthcare costs associated with long life (and there are big costs)and probably pay in taxes any cost to our healthcare system they take out, can you say the same thing?
admquilton
50 weeks ago
Smoking Alternatives
Noone yet has mentioned that electronic cigarettes might be a more credible answer here. There is already evidence that these can be extremely effective in curbing smoking, or even quitting.
Perhaps Canada should heed its neighbor to the south - A recent study at Boston University yielded some promising results.
morechatter
50 weeks ago
Up in smoke
I commend the premier in her desire to assist any one wishing to quit smoking. Perhaps a little more research so the help being offered to smokers will be a success and the valuable resources being used also dosen't go up in smoke.