Hunter S. Thompson, on a visit to Montreal, once described an acquaintance as "bright and ambitious, but he is cursed with a dark and twisted curiosity that all too often characterizes Canadians."

There could hardly be a better sketch of Canadian film director David Cronenberg. Curiosity has been the driving force in his auteurist career that spans six decades and has produced some of the most provocative films ever made. Almost a documentarian of his own imagination, Cronenberg has explored the mutated body and mind. His work is so distinctive that critics have coined the adjective "Cronenbergian."

One of the high points of his career came with his highly controversial film Crash (1996), about a subculture of people who fetishize car accidents and their byproducts. Cronenberg walked away from the Cannes film festival with a special jury prize for audacity.

Cronenberg's latest work, the psychological drama A Dangerous Method, is a beautifully-made, intelligent film, and has just been nominated for 11 Genies. But it won't win any prizes for audacity.

Cronenberg is definitely an auteurist director, and A Dangerous Method is definitely a Cronenberg film, with the classic Cronenberg protagonist, the scientific expert who is compromised by his own flaws. One of the director's earliest film concepts was Roger Pagan, gynecologist, about a neurotic man who impersonates a medical expert. In his current film, Sigmund Freud and Carl Jung (played by Viggo Mortensen and Michael Fassbender, respectively) are echoes of the mad scientists at the centre of his earlier films, while Sabina Spielrien (Keira Knightley) is the patient-turned-analyst who inspires both men and catalyses their separation.

It's hardly surprising that Cronenberg would make a film about the founders of psychoanalysis, based on a non-fiction book by John Kerr and a play by Christopher Hamptom. These men showed us our interiority and our dividedness, precisely the territory that Cronenberg explores. A century later, we no longer grant Freud and Jung the status of rational investigators, and see them more as artists than scientists -- flawed men who encoded their own prejudices and unquestioned assumptions about their theories about human nature. A Dangerous Method is Cronenberg documenting his own intellectual ancestors, now that the Victorian ideal of the rationally-ordered mind producing a rationally-ordered world is crumbling all around us.

All three characters are well-drawn, beyond the superficial caricatures of popular understanding. Freud, keeper of the new rationalist hope that human nature can be perfected, has good reasons for dictating a new orthodoxy. Jung, his heir apparent, turns to ideas like telepathy and mysticism because to him these are the next step in studying human nature. Spielrien is Jung's patient, his protégé, his uncredited collaborator and his masochistic mistress, but she is her own person, with her own boundaries and agency.

Set in an idyllic view of the Edwardian years, before the devastation of the First World War, this is a world of reason, beauty and order that has hidden chaos waiting to erupt. There are definite Cronenbergian visuals too: Spielrein's neurotic contortions and stammers before her treatment, Jung using an Edwardian precursor to the polygraph on his wife, the sudden outbreaks of sickness, violence, sexuality and uncontrollable emotions. But there are few such moments. The mannered restraint the characters aspire to practice seems to inform the film itself. The beauty Cronenberg applies to the film actually works against his story, giving it the superficial nostalgic appeal of a Merchant Ivory costume drama, which can obscure the fact that the world of these people will be shattered in the coming decades.

Cronenberg's next project is Cosmopolis, an adaptation of Don DeLillo's novel about a billionaire cruising in his luxury stretch limo through the pandemonium of Midtown Manhattan. This is a neat inversion of the opening of A Dangerous Method, with Knightley as a screaming, convulsing wretch locked inside a horse-drawn carriage travelling through the beautiful, orderly countryside. What a difference a century makes.

The overall trajectory of Cronenberg's film career is relentlessly inwards, from devastated cities to devastated minds. He has moved through different film genres like horror, science fiction, psychological thriller, literary adaptation, gangster story and soft-core pornography, always doing his own unique take on those staples.

Cronenberg's roots are in the horror and exploitation genres of the 1970s, the generation of filmmakers fostered by Roger Corman. IMDB.com still describes him as the "King of Venereal Horror or the Baron of Blood" (quite unlike the affable film geek persona he presents in interviews). His first feature, Shivers (1975), is his unique take on the zombie/social collapse genre of Night of the Living Dead and The Crazies, with artificial aphrodisiac-parasites spreading through the inhabitants of a Montreal apartment complex and making them run amok. It was financed in part by the Canadian Film Development Corporation (later known as Telefilm), part of the effort to create a domestic Canadian film industry. Robert Fulford condemned Shivers in Saturday Night magazine, calling it "the most repulsive movie I've ever seen" and saying to Canadian taxpayers, "You should know how bad this film is. After all, you paid for it." (Actually, Shivers made money.)

His next feature, Rabid (1976) starred porn queen Marilyn Chambers as a woman with an experimental skin graft that turns her into a rabies-spreading quasi-vampire. Distributors, used to gothic vampire flicks, had no idea what to do with these films. Right from the beginning, Cronenberg defied genre and critical conventions.

The 1980s brought him into maturity, working with larger budgets and name stars. Better effects technology fostered his interest in the grotesque, but he also pursued his interest in the intimate relationships of his characters. The Fly (1986) and Dead Ringers (1988) are so affecting because Cronenberg takes us inside the relationships of their characters and makes us care about them, even as their lives disintegrate into madness and decay. As bizarre as the endings of those two films are, they are also breathtakingly sad.